This book offers a holistic yet diverse perspective on how tourism destinations are facing three interrelated and critical challenges: the uncertainty created by COVID-19 and its subsequent effects; digitalization processes and transition towards smarter destinations; and the quest for sustainability in a sector affected by climate change, to which it is at the same time one of the main contributors. This publication looks at destinations' adaptation strategies to this complex scenario by offering a collection of eleven chapters authored by reputed scholars from universities in different countries (Australia, United States, Spain, Argentina, among others), that have been selected for their scientific value, quality and contribution. The contribution of these research works is not only theoretical and conceptual but also practical, as the book includes stimulating guidelines, proposals and examples for destination management organizations, planners, policy makers, and other decision makers. The variety of contents (theoretical discussions, case studies, best practices, empirical results, innovative methods…) offers valuable insights and useful references for students, researchers, educators, destination managers, planers, marketers and tourism companies. This book offers its readership a unique opportunity to learn about how tourism destinations are preparing themselves for an uncertain future by deploying strategies to become smarter, greener and more resilient.