Software systems currently support many of our daily task, however, the collaboration or interoperability between persons is few explored. This book goes beyond to the technical interoperability and face the knowledge heterogeneity of the actors involved in the Type 2 Diabets Mellitus care. The Generic Component Model is the framework for building interoperable systems starting from a computer independent view. Ontologies and business process models are combined in order to construct that computer independent view. Finally, a software solution is build and starts the path of a new generation of interoperable, knowledge-base, adaptable and reusable solutions.